Can Cats Have Down Syndrome? Short answer: No. Here’s why. Cat Down Syndrome is by definition an additional chromosome within the Chromosome 21 pairing in humans. Humans have 23 chromosome pairings where a cat only has 19. No 21st chromosome pair means no anomaly therein pairing. Cats simply don’t have enough chromosomes to possess what can properly be called mongolism . While some cats may display a number of symptoms like mongolism , the cause could also be another genetic fluke, poor nutrition or simply the cat being herself. Down Syndrome Signs In Cats And Kittens A cat or kitten may exhibit a number of the symptoms a person's with mongolism does. An undergrown kitten who isn’t reaching all the developmental milestones could also be affected by malnutrition or a genetic condition. Inbreeding and other factors can cause a cat to possess mental and physical abnormalities. Anemia and other blood disorders could also be thanks to parasitical infection...